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KMID : 0191120200350060079
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Journal of Korean Medical Science
2020 Volume.35 No. 6 p.79 ~ p.79
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Case of the Index Patient Who Caused Tertiary Transmission of Coronavirus Disease 2019 in Korea: the Application of Lopinavir/Ritonavir for the Treatment of COVID-19 Pneumonia Monitored by Quantitative RT-PCR
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Lim Jae-Gyun
Jeon Seung-Hyun
Shin Hyun-Young
Kim Moon-Jung
Seong Yu-Min
Lee Wang-Jun
Choe Kang-Won
Kang Yu-Min
Lee Baeck-Seung
Park Sang-Joon
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Abstract
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Since mid-December of 2019, coronavirus disease 2019 (COVID-19) has been spreading from Wuhan, China. The confirmed COVID-19 patients in South Korea are those who came from or visited China. As secondary transmissions have occurred and the speed of transmission is accelerating, there are rising concerns about community infections. The 54-year old male is the third patient diagnosed with COVID-19 in Korea. He is a worker for a clothing business and had mild respiratory symptoms and intermittent fever in the beginning of hospitalization, and pneumonia symptoms on chest computerized tomography scan on day 6 of admission. This patient caused one case of secondary transmission and three cases of tertiary transmission. Hereby, we report the clinical findings of the index patient who was the first to cause tertiary transmission outside China. Interestingly, after lopinavir/ritonavir (Kaletra, AbbVie) was administered, β-coronavirus viral loads significantly decreased and no or little coronavirus titers were observed.
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KEYWORD
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Coronavirus, COVID-19, Pneumonia, Tertiary Infection, Viral Load, Real-Time Reverse-Transcriptase Polymerase Chain Reaction
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